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Avoid driving and other potentially dangerous tasks if Percocet makes you sleepy. You should also avoid alcohol and other sedatives, unless your doctor says they're OK to take. Taking it with or without food may help with nausea or vomiting. Try both to see what works for you. Opioids such as Percocet latch on to opioid receptors in the brain. They can create a sense of euphoria and numb pain, but they can also slow breathing. Percocet, Percodan, and Tylox are other trade name oxycodone products. Oxycodone is a central nervous system depressant. Oxycodone's action appears to work through stimulating the opioid receptors found in the central nervous system that activate responses ranging from analgesia to respiratory depression to euphoria.